Learn ➜  Interior Medicine Method ➜  Part 1

A Framework for Assessing Any Health Risk in Your Home

"Toxic" without context is meaningless. Here's a framework for making decisions about the risk of any product in your home.

By Dr. Meg Christensen | Updated March 2026


The Framework
01
Hazard
What is the worst this exposure could do?
02
Exposure
Does it actually reach you?
03
Dose
How much gets into your body?
04
Dose-Response
What does it do at that dose?
+
05
Susceptibility
How vulnerable are you?
06
Risk
What's the probability of harm?
click through each concept in order
The fundamental equation
Hazard x Dose x Susceptibility = Risk

Hazard is what an exposure is capable of doing, a fixed property of the substance or stressor itself. Dose is the amount that actually reaches your organs and tissues, not just what you were near or touched. Susceptibility determines how you specifically will respond. Your age, genetics, health status, and life stage all shape the outcome. Risk is the probability that harm will actually occur, given this specific combination in your specific situation. It is the output of the whole framework, not a property of the substance alone.

Hazard is not Risk
This is the single most important distinction in all of toxicology, and the one most exploited by fearful wellness content and by dismissive industry communications alike. A substance can be intensely hazardous yet pose negligible risk if exposure is essentially zero. Conversely, a relatively mild hazard at high enough doses in a vulnerable person can pose meaningful risk.
Exposure is not Dose
Being near something is not the same as absorbing it. Route matters enormously: a substance that cannot penetrate skin poses negligible risk dermally but high risk if inhaled or ingested. Form matters too: the same element in different chemical compounds can have dramatically different bioavailability. What you are exposed to and what actually reaches your organs are two different things.
Threshold, No-Threshold, and Other Shapes
Most exposures follow a threshold model: below a certain dose, no measurable harm occurs. Carcinogens often follow a linear no-threshold model: any dose carries some risk, however small. And for endocrine disruptors, researchers are increasingly documenting non-monotonic (U-shaped or inverted U-shaped) curves, where low doses produce different effects than high doses. The shape of the curve matters for how safe levels are set.
But Wait: Three Exceptions
The framework above helps you assess an exposure for yourself. But risk is not only personal. Read on for three situations that complicate the picture: when benefits outweigh risks, when workers upstream bear a higher burden than you do, and when what you discard becomes someone else's exposure.

Three Exceptions

If you’re up for injecting a little complexity into the above, there are three times when the six-step framework calls for a little more nuance.

1. Do the benefits outweigh the risks?

Sunscreen contains chemicals that absorb through skin (risk) but it also prevents skin cancer (benefit.) X-rays involve radiation exposure (risk) and enable life-saving diagnoses (benefit.) A possibly-lead-containing vintage lamp (risk) from your grandma reminds you of her (benefit) so you keep it on your shelf. In short, even if you get to the end of the framework and some risk is present, you may decide there’s enough benefit outweighing it. This depends on your unique risk tolerance level and personality, and the answers won’t be the same for everyone.

2. Before You: The Workers Making It

Here is where it starts getting a little more tricky: every product has a life before it reaches you. The chemicals used to process textiles, treat wood, apply coatings, or manufacture foam are often present in much higher concentrations in the factory they’re made in than they ever will be in your home. Workers in these facilities are exposed at levels that dwarf what you'll encounter as an end user. This is why Prop 65 warnings sometimes say more about factory conditions than about your living room, and why certifications like GOTS matter beyond what's in the final product: they set standards for the entire production process, including what workers are exposed to.

What's healthy for you as the end user isn't always the healthiest option for the people making it. It’s worth keeping in mind, even if the answer isn’t always clear or consistent, and doesn't change your immediate purchasing decision.

3. After You: Other People and The Environment

The trickiest caveat of all: the chemicals in a product you discard don't disappear. They enter landfills, wastewater treatment, soil, and water systems, and eventually some cycle back into the food and water supply. PFAS in particular are notorious for this: they've been found in drinking water far from any known point source, carried there through the water cycle.

This is part of why avoiding certain chemical classes matters at a societal level even when individual exposures seem small, and why buying only what you need matters. This is a major criticism of the wellness world, and I understand why.

An example: an OEKO-TEX certified polyester blanket poses relatively low risk to your health, and its accessibility compared to organic alternatives is important. But polyester is petroleum-derived, and the extraction and refinement involved carries costs for the planet and the communities near those facilities, as well as the landfill that will contain it in the future, because polyester is a plastic that doesn’t break down easily. This is not an argument against buying OEKO TEX certified polyester. It's an acknowledgment that buying healthier products for your home isn't a complete answer to a much larger question. That conversation is global, political, and ethical, and well beyond what a few paragraphs here can resolve. But, I think it’s important for all of us to consider, and it’s important to me that you know I’m aware of this complexity.

Now that you understand this basic framework for assessing products, we’ll dive into each concept, starting with Hazard. What hazards are in your home, why they’re hazards, and which ones to pay attention to.

Next: What Your Home Exposes You To

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Learn ➜  Interior Medicine Method ➜  Part 1