Base Formula Guide

How healthy a product’s base formula is comes down to three things: whether every ingredient is disclosed, whether any are listed as a health hazard for how you use the product, and how it gets into your air (burned, sprayed, or left to evaporate.) This guide covers everything but the scent in candles, wax melts, diffusers, room sprays, soaps, detergents, and cleaners, and rates it on one consistent scale. The scent itself rated separately in my Fragrance Guide. The Base Formula Rating Scale is part of the Interior Medicine Method.

By Dr. Meg Christensen | Physician-founder of Interior Medicine, a non-toxic home resource built on her background in medicine, biochemistry, epidemiology, and clinical research.

Published Nov 1, 2026   |    Updated Nov 1, 2026

What This Guide Covers

Table of Contents‍ ‍

Hazard Lists & Third-Party Certifications for Base Formulas

Formulas for Home Fragrance: Candles, Wax Melts, Diffuser Oils

FYI: How and why I use the words non-toxic, chemical-free, toxin, and toxic

Base Formula Rating Scale

This scale is a summary of all the information below. Scales keep me consistent and unbiased as I rate and rank products for their potential impact on your health and they’re meant to organize the information in a straightforward way for you, too. Keep reading for the full breakdown on the reasoning behind it, and how to make smart decisions about using products in your home.

Base Formulas Rating Scale

TIER 01

Healthiest

Description

Fully disclosed, with no ingredient listed as a health hazard by a major health authority for how you use it, and nothing burned or misted

Any product

  • Every ingredient named, including the preservative
  • No isothiazolinone or formaldehyde-releasing preservatives, and no dyes or optical brighteners

Soaps, detergents & cleaners

  • Surfactants that aren't ethoxylated, or a published test showing no detectable 1,4-dioxane

Home fragrance

  • Raw plant material, or a hydrosol with no alcohol, preservative, or dye, in a regular spray bottle

Look for

  • A full ingredient list that names the preservative
  • Surfactants like decyl glucoside, coco-glucoside, or saponified plant oils (sodium olivate, potassium cocoate)
  • "No dyes," "no optical brighteners"

Ask the brand

  • Which preservative is used, if any?
  • Has the formula been tested for 1,4-dioxane?

In practice

  • Some small-brand hand soaps, dish soaps, and laundry detergents reach this
  • Products with no preservative can spoil, so check for a use-by date

Evidence

1,4-Dioxane is a byproduct of ethoxylated surfactants, and New York caps it at 1 ppm in household cleaning products (NY DEC). No emission studies were found for hydrosols or raw scented wood.

TIER 02

Healthy

Description

Fully disclosed with an added dye, or a named natural base that's heated or diffused without a flame

Any product

  • Added dyes and optical brighteners drop any product one tier, so a product that otherwise meets Healthiest lands here

Home fragrance

  • A named base of water, plant oil, beeswax, or plant wax in a regular spray bottle, reed diffuser, sachet, plug-in, or wax warmer
  • A beeswax or plant wax candle melted under a candle-warmer lamp instead of lit. With no flame, a candle makes no combustion particles

Look for

  • "100% beeswax," "coconut wax," "plant wax"
  • A named carrier oil or water base

Ask the brand

  • Is any dye or optical brightener added?
  • What is the base or carrier?

In practice

  • A candle-warmer lamp moves a clean beeswax or plant wax candle up from OK to here
  • Fully disclosed plant-based soaps and detergents with added color land here

Evidence

A chamber study of a reed diffuser found its emissions were scent VOCs, concentrated near the diffuser (Zhang 2024). A plug-in diffuser significantly raised VOCs only in the least-ventilated quarter of 60 homes (Warburton 2023).

Scented wax melts released more monoterpenes per gram of wax than scented candles (Purdue zEDGE study), and those terpenes reacted with indoor ozone to form nanoparticles at doses similar to combustion sources. Unscented wax melts released no significant terpenes, so the concern comes from the scent, which is rated on the Fragrance scale (Patra 2025). No data was found for candle-warmer lamps.

TIER 03

OK

Description

Partial disclosure, untested surfactants, petroleum or solvent bases, mists, aerosols, or the cleanest lit candles

Any product

  • Ingredients listed only to the level the law requires, or by function ("surfactant," "preservative")
  • A third-party seal (EPA Safer Choice, National Eczema Association) without a full public ingredient list
  • Aerosol cans

Soaps, detergents & cleaners

  • Ethoxylated surfactants (names ending in "-eth" or starting with "PEG") with no 1,4-dioxane testing

Home fragrance

  • Paraffin wax melts, mineral oil plug-ins, or alcohol or dipropylene glycol carriers
  • Ultrasonic diffusers, which can add fine particles to the air, and nebulizers, which haven't been tested
  • Lit candles at their best: beeswax or plant wax with a named cotton, paper, hemp, or wood wick with no metal core. No candle rates higher, because every open flame makes combustion particles

You'll see

  • "Plant-based surfactants" with none named
  • "Sodium laureth sulfate," "PEG-"
  • A Safer Choice or NEA seal
  • "Cotton wick," "wood wick"

Ask the brand

  • Can you share the full ingredient list?
  • Has the formula been tested for 1,4-dioxane?
  • Is the wax blended with paraffin? Does the wick have a metal core?

In practice

  • Where many mainstream "natural" detergents land
  • The best a lit candle can do
  • Trim the wick and keep candles out of drafts to reduce soot
  • Fill ultrasonic diffusers with distilled water, not tap water

Evidence

In homes that burned candles, candles caused almost 60% of residential ultrafine particle exposure (Bekö 2013). In the largest controlled candle study, most pollutants stayed below guidance values, with exceptions in some cases for nitrogen dioxide, acrolein, and benzo[a]pyrene (Salthammer 2021). The beeswax candle tested emitted the fewest pollutants, and the gel candle the most (Lee & Wang 2006). Sooting burns produce the highest particle mass, and smoldering after a candle is put out adds more (Pagels 2009).

Filling an ultrasonic diffuser with tap water instead of deionized water raised fine particle emissions fivefold (Schwartz-Narbonne 2021). New York caps 1,4-dioxane at 1 ppm in household cleaning products (NY DEC). No data was found for nebulizers.

TIER 04

Use Caution

Description

Skin-sensitizing preservatives, disinfectants, undisclosed bases, conventional candles, or the cleanest incense

Any product

  • An undisclosed or "proprietary" preservative or base

Soaps, detergents & cleaners

  • Isothiazolinone preservatives (methylisothiazolinone, methylchloroisothiazolinone, benzisothiazolinone) or formaldehyde-releasing preservatives (DMDM hydantoin, quaternium-15, diazolidinyl urea, imidazolidinyl urea, bronopol) in anything that touches skin. In dishwasher detergent, these count one tier lighter, since you don't handle what's in the machine
  • Disinfectants like quats (benzalkonium chloride, didecyldimethylammonium chloride) or chlorine bleach, especially in sprays

Home fragrance

  • Lit candles with paraffin or paraffin blends, gel wax, undisclosed wax, or a zinc, tin, or unnamed metal-core wick
  • Catalytic lamps, which burn alcohol on a heated stone
  • Incense, smudge bundles, or resin on charcoal at their best. These smolder, which releases far more particles than an open flame, so they never rate higher

You'll see

  • "Methylisothiazolinone," "DMDM hydantoin," "benzalkonium chloride," "sodium hypochlorite"
  • "Disinfects" or "kills 99.9% of germs"
  • "Paraffin," "wax blend," or no wax named
  • "Pure resin" or "natural" incense

Ask the brand

  • Which preservative is used?
  • Is there a version without a disinfectant?
  • What wax is this, and is any paraffin blended in?

In practice

  • The default for most conventional dish soaps, detergents, and disinfecting cleaners
  • Clean incense lands here, never higher, because smoldering is the most polluting way to scent a room

Evidence

Methylisothiazolinone was the 2013 American Contact Dermatitis Society Allergen of the Year and turns up most often in dish soap (isothiazolinone allergy review), and formaldehyde releasers sensitize roughly 0.4% to 1.9% of patch-tested patients in Europe (de Groot 2010). Quats were the main cause of sensitizer-induced asthma in cleaners given inhalation challenge tests (Vandenplas 2013). Women who cleaned at home had faster lung function decline over 20 years (Svanes 2018), and weekly home bleach use was linked to modestly more childhood infections (Casas 2015).

Zinc-core wicks emit zinc and small amounts of lead (Nriagu & Kim 2000). Incense emitted over 48 mg of PM10 per hour, while candles emitted well under 1 mg (Stabile 2012), and long-term incense use carried a 1.8 relative risk of respiratory squamous cell carcinoma in 61,320 adults (Friborg 2008).

TIER 05

Harmful

Description

Known harmful chemistry

Any product

  • Any ingredient, disclosed or found in testing, that the EU bans in cosmetics, the EU classifies as a category 1A or 1B carcinogen, mutagen, or reproductive toxin, or IARC classifies as Group 1 or 2A
  • PFAS

Home fragrance

  • Lead-core wicks

You'll see

  • Ingredients with "fluoro" in the name
  • Imported or old candles with a stiff metal-core wick and no wick disclosure

Ask the brand

  • Does any ingredient contain PFAS?
  • Has the wick been tested for lead?

In practice

  • Rare in products sold as non-toxic
  • Lead-core wicks are banned in the US, but older and imported candles can still have them

Evidence

Of 100 candles tested, 8 had lead-core wicks that emitted 100 to 1,700 µg of lead per hour (Wasson 2002). The US has banned them since October 15, 2003, above 0.06% lead in the metal core (CPSC).

HAZARD

Decoder

Prop 65

A Prop 65 warning means the brand either knows a listed substance is present above a regulatory limit, or is labeling as a legal precaution. Each chemical can look alarming at first glance, but there's more nuance to whether you need to worry. The most common base-related reasons for a warning are:

  • Benzene, formaldehyde, carbon monoxide, and soot: made by burning. Prop 65 covers exposure while you use a product, not just what's in it, so a candle, incense, or catalytic lamp can need a warning even when the wax and scent are clean. Incense makes more than candles.
  • 1,4-Dioxane: a byproduct of ethoxylated surfactants, not an added ingredient, so it never appears on a label. Testing is the only way to know.

Scent-related warnings (phthalates, methyleugenol, benzophenone) are covered on the Fragrance scale.

Evidence gaps and funding

The most controlled candle comparison (Salthammer 2021) was funded by the European, US, and Latin American candle associations and designed with candle manufacturers and fragrance houses. Its data is still the best available. A study finding scented candles pose no known health risks under normal use was co-authored by fragrance and consumer-goods companies, including SC Johnson and Procter & Gamble (Petry 2014). The 60-home plug-in study included co-authors from a fragrance house and a home fragrance retailer (Warburton 2023).

The often-cited claim that paraffin is worse than soy comes from a conference presentation with no peer-reviewed paper. I don't rely on it.

Most evidence on quats and asthma comes from workplace studies, and population studies of cleaners don't consistently show it (LaKind & Goodman 2019). Household data is limited.

No data was found for wood vs. cotton wicks, candle-warmer lamps, nebulizers, catalytic lamps beyond chamber testing, dyed vs. undyed candles, or reed diffuser carriers.

Formulas for Home Fragrance

What else is in a fragrance besides the scent?

Home fragrance is never just scent molecules. It’s also what carries the scent and how it gets into the room. For example:

  • Scented candles are wax, wax additives, what the wick is made of, and molecules created by burning.

  • Scented room sprays contain water, surfactants, and preservatives

  • Incense is scented powder blended with resin, bamboo stick, and molecules created by burning.

Why do fragrances have surfactants?

Oil and water don’t mix, so most water-based fragrances like room sprays, linen sprays, and diffusers need a surfactant (also called a solubilizer) to hold an oil-based fragrance in the water. Common ones are polysorbate 20, polysorbate 80, and PEG-40 hydrogenated castor oil. These are ethoxylated ingredients, which means they can carry trace 1,4-dioxane and ethylene oxide from manufacturing and they are being restricted in some states.

Do fragrances contain preservatives?

Water-based products like room sprays and water-based diffusers do need preservatives, however, so often contain isothiazolinones (like methylisothiazolinone), phenoxyethanol, or sodium benzoate. Methylisothiazolinone is a well-documented skin allergen so the EU and Canada have restricted it, though the US hasn’t.

Fragrance oils don’t need preservatives because bacteria and mold don’t grow in oil. Many fragrance oils do contain antioxidants, like BHT or tocopherol (vitamin E), to keep the scent from oxidizing.

Search any of these preservatives for what they do and where they’re restricted or banned on my Check a Fragrance page.

What is a dispersal method?

This is a fancy way of describing how the scent gets thrown into your room. It can happen through simple evaporation, forced out as little tiny particles like happens in nebulization, it can be burned or smoldered, like a candle or incense. It’s an important part of how healthy a fragrance is because burning anything in your home produces soot, nebulizers can create ultrafine particles, and simple evaporation adds nothing harmful.

What is evaporation?

Evaporation is when a liquid scent drifts into the air on its own over time, similar to how a puddle evaporates on a sunny day. This is how reed diffusers, scented gels and beads, sachets, and potpourri work. It’s also what happens after you spritz a scent from a regular pump or trigger bottle: the water evaporates into the air.

Fan diffusers speed up the process. They blow air across a pad soaked in scent. Think of using a small fan to help the scent evaporate faster.

Evaporation adds the fewest extra things to your air. There’s no flame or propellant-forced mist, so what you breathe is mostly the scent molecules themselves. That doesn’t make it risk-free: scent molecules still react with ozone indoors no matter how they get into the air (more on that in the scent section above).

What is nebulized or ultrasonic diffusion?

Ultrasonic and nebulizing diffusers work differently from evaporation, including evaporative fan-based diffusers. They push tiny droplets into the air.

Ultrasonic diffusers hold water with a few drops of oil. A plate vibrates at a high frequency and breaks the water into a fine mist that carries the oil with it. Anything else in the water goes airborne too. The EPA notes these devices are very efficient at releasing the minerals in tap water into the air, and a Virginia Tech study found tap water in an ultrasonic humidifier raised room particle counts nearly 13 times, while distilled water raised them only slightly. That research was on humidifiers, which use the same technology. If you use an ultrasonic diffuser, use distilled water.

Nebulizers use no water at all. They turn undiluted fragrance oil into an aerosol, so you get a more concentrated output.

Both produce small airborne particles. Chamber studies have measured particles in the 10–100 nanometer range from ultrasonic diffusers, which is small enough to reach deep into the lungs. The research here is early, and the health effects of routinely breathing nanoparticles from diffusers aren’t well characterized. I think caution is reasonable.

What are aerosols?

Technically, an aerosol is any suspension of fine liquid or solid particles in air, so every spray makes one. But in normal everyday use, “aerosol” means a pressurized can that uses gas to propel the contents out as a very fine mist. Think spray paint, or canned room sprays like Febreze Air.

The difference from pressurized bottles and regular bottles is how long the particles stay in the air. In a chamber study of cleaning sprays, particles from pressurized cans took about twice as long to settle as particles from regular spray bottles. More time in the air means more time to breathe it in, so it’s more important that the scent is safe.

What are propellants?

Propellants are the compressed gases in aerosol cans that force the scent out as a powerful mist. In the “olden days,” this gas was CFCs, or chlorofluorocarbons. The US banned CFCs as aerosol propellants in 1978 because they damage the ozone layer. Brands mostly switched to hydrocarbon propellants so today that usually means propane, butane, and isobutane, or compressed gases like nitrogen or CO2. Since propellants are released into the air along with the product, what they are can impact your indoor air quality. Even if they come out in very small quantities with each spray, if you use a spray very often, it can potentially add up.

What is the difference between nitrogen and other gas propellants?

Hydrocarbon propellants like propane, butane, and isobutane are the most common in consumer aerosols. They’re flammable and add to your indoor VOC load, though a single spray delivers a small amount.

The bigger concern is contamination. Starting in 2021, an independent lab found benzene, a known human carcinogen, in many personal care aerosols. The FDA pointed to the propellant isobutane as one possible source. Those were deodorants, dry shampoos, and sunscreens, not air fresheners. But they show the broader problem: aerosols contain several ingredients besides the scent, and full disclosure is rare.

Nitrogen is the most inert option because it doesn’t react with much. It’s less common because it doesn’t keep pressure as steady as the can empties. If a safety data sheet lists nitrogen as the propellant, that’s the better choice among aerosols. Skipping aerosols for home fragrance altogether is the simpler move when alternatives exist.

And yes, it’s true that one spray won’t hurt you on its own. But, we’re constantly exposed to poor air quality, so if you can make this change without added stress, I think it’s a good idea.

FYI: How and why I use the words non-toxic, chemical-free, toxin, and toxic

I use the words non-toxic, chemical, toxin and toxic, even though there is no agreed-upon definition of the term non-toxic, and that everything, even water, is made of chemicals, so nothing is truly chemical-free. Likewise, toxin refers to a natural substance like a plant poison or venom, whereas toxicant is a more accurate term for the chemicals in products that have a negative health impact. I recognize that something that is toxic does not automatically make it a health risk.

I choose to use these scientifically inaccurate words anyway purely for practical purposes, for now. This is because these words are currently the most culturally agreed-upon, descriptive, and accessible terms that allow people to find the information they’re looking for.

In short, “non-toxic” is shorthand for a complicated problem. I’ll update my terminology if this changes!

Don’t see what you’re looking for? Request a review, or check it yourself in seconds with the Second Opinion Product Checker. Spot something outdated? Let me know and I’ll update it. Join the spam-free newsletter for interesting info and to hear when new reviews are up.

FYI, “non-toxic” has no official definition, so I rate every product with the same method. It’s built on third-party certifications and published test data, not brand claims. For a deeper dive, my free course walks you through it.

Everything on Interior Medicine is educational information, not medical advice. Read my full disclaimer.